Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
نویسندگان
چکیده
منابع مشابه
Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
Sphingolipids have important roles in membrane and lipoprotein structure and in cell regulation as second messengers for growth factors, differentiation factors, cytokines, and a growing list of agonists. Bioactive sphingolipids are formed both by the turnover of complex sphingolipids and as intermediates of sphingolipid biosynthesis. Usually, the amounts are highly regulated; however, by inhib...
متن کاملEvidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins.
Fumonisins are inhibitors of the biosynthesis of sphingosine and more complex sphingolipids. In eucaryotic cells, fumonisin inhibition of sphingolipid biosynthesis is a result of inhibition of the enzyme ceramide synthase. Large increase in free sphinganine concentration in plant and animal cells are observed within a few hours after exposure to fumonisins and/or Alternaria toxins (AAL-toxins)....
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2001
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.01109s2283